Episodes
Science Corner Special! David Friedberg, Cleo Abram, Alex Filippenko, and Keller Rinaudo Cliffton
All-In Podcast
9/29/2025
In a special Science Corner edition hosted by David Friedberg at the All-In Summit, the discussion features three innovators at the forefront of science communication and technology. The first guest, Cleo Abram, shares her journey from being a journalist at Vox to becoming a leading independent creator on YouTube with her channel Huge If True. She explains how the platform has enabled a new Creator Economy, allowing her to pursue her mission of spreading Techno-optimism by showcasing how technology can solve complex problems. Next, astrophysicist Alex Filippenko from UC Berkeley delivers a presentation on the revolutionary James Webb Space Telescope, a project born from International Collaboration led by NASA. He details how the telescope is providing unprecedented views of the early universe, studying Exoplanets for signs of life, and challenging existing models of galaxy formation. In the Q&A, Filippenko reaffirms the robustness of the Big Bang Theory using evidence like the Cosmic Microwave Background Radiation, explores intriguing concepts like Black holes, the Fermi Paradox, and the Great Filter, and argues for funding pure research by highlighting its history of producing major Technological spin-offs from fields like Quantum physics. He concludes with a stark warning about recent cuts to scientific funding, specifically mentioning NIH Grants. Finally, Keller Rinaudo Cliffton, co-founder and CEO of Zipline, presents his company's pioneering work in creating the world's
Inside the GLP-1 Gold Rush: Eli Lilly CEO on New Breakthroughs, Addiction & Mental Health, Pricing
All-In Podcast
9/28/2025
In a detailed discussion, Eli Lilly CEO Dave Ricks unpacks the story behind the 'GLP-1 Gold Rush,' charting the evolution of GLP-1 drugs from a treatment for Diabetes to a revolutionary therapy for Weight Loss and Obesity. He highlights the phenomenal success of Tirzepatide, which surpassed Keytruda as the world's top-selling drug in Q2. Ricks confronts the controversial topic of GLP-1 Pricing, explaining the delicate balance between increasing access and funding future R&D, while also announcing an upcoming Oral GLP-1 pill. A significant portion of the company's strategy involves aggressive Capital Allocation towards expanding its Supply Chain by building numerous manufacturing plants in the United States, a commitment he references in connection with President Trump. The conversation also explores major market headwinds, including the proliferation of Counterfeit Products from China, the strategic threat of Patent Hacking which is influenced by the American Invents Act, and the challenging investment climate for Biotech VC. Looking ahead, Ricks reveals unexpected applications for GLP-1s in curbing Addictions and treating Mental Health conditions, potentially disrupting the market for SSRIs. He also touches on broader industry issues, criticizing the role of PBMs, questioning the efficiency of NIH funding, and explaining how outdated FDA regulations shape modern Pharma Advertising. Ricks sees AI in Healthcare as a positive force for patient empowerment and predicts t
H-1B Shakeup, Kimmel Apology, Autism Causes, California Hate Speech Law
All-In Podcast
9/26/2025
In this episode, the All-In Podcast hosts Jason Calacanis, Chamath Palihapitiya, David Sacks, and David Friedberg dive into several major topics. They begin with a detailed analysis of the Trump Administration's proposed overhaul of the H-1B visa program, including a new $100,000 fee. The hosts largely agree that the system has been abused, particularly by IT consulting firms practicing labor arbitrage, to the detriment of American workers. David Friedberg suggests a modern-day Operation Paperclip as a more strategic alternative for talent recruitment, while Chamath Palihapitiya notes that OPT already provides a pathway for high-skilled graduates. Next, they tackle the controversial press conference held by Donald Trump and Bobby Kennedy regarding a potential link between Autism and Tylenol (acetaminophen) use during pregnancy. They discuss a paper by Andrea Bakarelli and explore a scientific theory involving autoimmunity and the folate receptor. The conversation then shifts to the return of Jimmy Kimmel to ABC following his suspension by parent company Disney. The hosts debate his apology concerning comments made about the Murder of Charlie Kirk and his alleged linkage of the shooter to MAGA, which leads to a broader discussion on the rise of Left-wing political violence and an Assassination Culture. In the technology segment, two significant AI papers are highlighted: one from MIT on teaching LLMs to reason through symbolic planning, and another from Germa
Eric Schmidt on AI, the Battle with China, and the Future of America
All-In Podcast
9/24/2025
Former Google CEO Eric Schmidt presents a multifaceted worldview for founders, touching on technology, geopolitics, and business strategy. He strongly opposes Remote work for young professionals, advocating for in-person mentorship. Schmidt provides a nuanced analysis of the US vs China AI competition, explaining that while the US pursues ambitious goals like AGI (Artificial General Intelligence), China is strategically focused on applying existing AI to everything, from consumer apps to robotics, and is winning global influence by promoting Open source AI, a direct challenge to the predominantly Closed source AI approach of the West. This competition is underscored by China's intense 996 work culture and technical advances in areas like Numeric Precision in AI. On the hardware front, Schmidt discusses his leadership at Relativity Space, which builds Rockets to compete with SpaceX, and offers profound insights into the evolution of warfare based on the Ukraine War. He describes Drone warfare as a paradigm shift, where cheap Drones can neutralize expensive military assets, and where Ukraine effectively uses technologies like Starlink for command. Geopolitically, Schmidt voices concerns about the Decline of the West and global Population Decline, but ultimately champions American exceptionalism, urging the nation to leverage its unique strengths in capital markets and innovation. On the future of AI, he counters the San Francisco narrative by predicting AGI (Artificial Genera
Charlie Kirk Murder, Assassination Culture in America, Jimmy Kimmel Suspended, Ellison Media Empire
All-In Podcast
9/19/2025
This episode of the All-In Podcast provides an in-depth analysis of the Murder of Charlie Kirk, treating it as a critical inflection point for American society. The hosts, David Sacks, Chamath Palihapitiya, Jason Calacanis, and David Friedberg, begin by mourning Charlie Kirk, the influential founder of Turning Point and a key figure in the MAGA movement, whom Sacks considered a friend. They dissect the profile of the killer, Tyler Robinson, framing him as an exemplar of a lost COVID Generation suffering from Online Radicalization and an ideologically incoherent worldview dubbed Salad Bar Extremism. This act is viewed as a stark manifestation of a rising Assassination Culture and the growing acceptance of Political Violence, which threatens to destroy Public Discourse and the principle of Free Speech. The conversation then shifts to the media's reaction, focusing on the Suspension of Jimmy Kimmel by ABC. The hosts detail how Kimmel's false accusation against the MAGA movement led to his downfall, which was accelerated by pressure from the FCC under Brendan Carr and the network's largest affiliates, NextStar and Sinclair, igniting a debate on Cancel Culture versus consequences. This media turmoil serves as a backdrop for a discussion on the strategic moves shaping the future of media, particularly the rise of the Ellison Media Empire. They analyze how David Ellison of Skydance and his father Larry Ellison of Oracle are driving Media Consolidation with th
Solana’s Anatoly Yakovenko on Crypto's Next Era: Quantum, AI, and the Future of Money
All-In Podcast
9/18/2025
In a comprehensive discussion on the future of crypto, Anatoly Yakovenko, CEO of Solana Labs and co-founder of Solana, outlines the industry's evolving landscape. He highlights a dramatic improvement in the US regulatory environment, crediting figures like David Sacks for a positive shift away from what he describes as the hostile regime of Gary Gensler. Yakovenko is optimistic about legislation like the Genius Act, predicting it will unlock trillions in Stablecoins, which will in turn drive massive demand for US Treasuries and help export American Finance globally. He strategically differentiates Solana as the 'World's Execution Layer' focused on speed, from its competitor Ethereum, founded by Vitalik Buterin, which he defines as the 'World's Settlement Layer. ' Institutional interest is growing, as shown by BlackRock building on Solana and traditional players like Nasdaq exploring Tokenization of Securities. Looking ahead, Yakovenko sees immense potential in verticals like the Creator Economy on Blockchain, which requires the legal framework of the CLARITY Act to flourish, and in bringing Real World Assets on Blockchain to enhance risk management in DeFi. He also addresses significant technological challenges, warning that a breakthrough in Quantum Computing, potentially accelerated by AI, threatens current Cryptography. This necessitates a proactive migration of platforms like Bitcoin to Quantum-Resistant Cryptography, a move that would likely follow adoption by te
Uber CEO Dara Khosrowshahi on self-driving's future, changing business model, job displacement
All-In Podcast
9/17/2025
In a detailed discussion, Uber CEO Dara Khosrowshahi elaborated on the company's multifaceted strategy for navigating the future of transportation, with Autonomous Driving at its core. He emphasized that Uber's strength lies in its Network Effects, positioning it as an ideal platform to support the entire AV Ecosystem by maximizing vehicle utilization for partners. This is demonstrated through existing partnerships with leaders like Waymo in Atlanta and Austin, and numerous emerging players in China, a market rapidly advancing in Level 4 Autonomy. Khosrowshahi contrasted Waymo's sensor-rich approach using LiDAR and HD Maps with Tesla's Computer Vision-only strategy, extending an open invitation to Elon Musk to bring Tesla Robotaxis onto Uber's network to boost revenue for their owners, which Musk envisions as 'Digital Shepherds'. Uber's business model will transition to a Hybrid Network of human drivers and autonomous cars, largely maintaining its Asset-light business model long-term, despite a willingness to use its balance sheet to accelerate adoption. This financial strength is evidenced by a $20 billion Stock Buyback. Beyond ground transport, Uber is investing in the third dimension of urban mobility with EVTOL technology through its stake in Joby, and is innovating in its Uber Eats division with Sidewalk Robots and Drone Delivery. Khosrowshahi also noted a continuing working relationship with ventures from founder Travis Kalanick, such as Cloud Kitchens, and cand
The College Crisis: Heads of Dartmouth & Berkeley Debate the Decline of US Universities
All-In Podcast
9/16/2025
In a comprehensive debate on the crisis facing US Universities, Dartmouth President Sian Beilock and Berkeley Chancellor Rich Lyons addressed the eroding business model and public trust in higher education. The discussion was framed by the challenges of massive Student Loan Debt, which is tied to the Federal Student Loan Program, the questionable ROI of Higher Education for many graduates, and the internal problem of Administrative Bloat, which Rich Lyons specified Berkeley is tackling through an initiative against Bureaucratic Burden. The university leaders also delved into cultural issues, with both agreeing on the need to improve Viewpoint Diversity. Sian Beilock argued that DEI and merit are not mutually exclusive and emphasized the importance of Institutional Neutrality and Free Expression, referencing the University of Chicago as a model. The conversation touched on the external pressures from politics, such as actions by Donald Trump impacting the Ivy League (including Harvard), and the legal landscape shaped by the Supreme Court's rulings on Affirmative Action—a policy long banned in California. A significant concern raised was the K-12 Education Decline, which sends academically and socially unprepared students to college. Looking forward, the transformative potential of AI and AI in Higher Education was examined as a major disruptor, though a potential conflict with Teachers Unions was predicted. Despite challenges like Rising Graduate Unemployment, the lead
Robinhood CEO Vlad Tenev on tokenizing stocks, expanding access to private shares, fintech's future
All-In Podcast
9/15/2025
In a detailed discussion, Vlad Tenev, the CEO and founder of Robinhood, outlined the company's vision and recent strategic moves, notably its inclusion in the S&P 500. The core of the conversation centered on the innovative strategy of Tokenizing Securities, where Robinhood uses Blockchain technology to offer fractional ownership of private companies like OpenAI and SpaceX. This initiative was first launched in Europe with the goal of eventually bringing it to the US to provide retail investors with Access to Private Company Shares. This move prompted conversations with OpenAI's CEO, Sam Altman, and highlights the regulatory complexities involved. Tenev described a markedly improved relationship with the current White House administration compared to the last, seeing it as more open to innovation, though he still faces staunch opposition from critics like Senator Elizabeth Warren over concerns of Consumer Protection in Fintech. To achieve his vision in the US, Tenev advocates for a Relaxation of Accreditation Standards, pointing to the Genius Act for Stablecoins as a positive regulatory precedent from the US Government. The discussion also explored the broader market trend of Fintech Convergence, positioning Robinhood's ambition to become a Comprehensive Financial Platform as a direct challenge to fintech peers like Coinbase and Stripe, and financial incumbents like JP Morgan, Visa, and Mastercard. The podcast also featured a story from early investor Jason