Topics & People

Bryan Johnson's core philosophy, which he frames not just as a health goal but as the next major ideology for humanity, on par with democracy or capitalism.

Entrepreneurs launching businesses influenced by VC valuations.

The region of the brain responsible for executive functions like willpower. Johnson states that its function is severely impaired by a lack of sleep.

A cognitive function that Johnson explains is directly dependent on sleep quality, as sleep deprivation causes the prefrontal cortex to go offline.

A key biomarker Johnson advises monitoring and lowering before bedtime, as he claims it is the best predictor of sleep quality and a lever for overall health improvement.

Identified by Bryan Johnson as the single most critical factor for health, willpower, and overall well-being. He refers to it as the 'best performance-enhancing drug'.

A method to assess the functional age of the body and its individual organs, which can differ from chronological age. Johnson uses it as a key performance indicator for his health regimen.

The scientific and strategic pursuit of extending human healthspan and lifespan.

A mobile payment service company that Bryan Johnson previously founded and sold for $800 million, providing him the resources for his longevity project.

A financial framework used to construct portfolios to optimize or maximize expected return for a given level of risk. Ark used this theory to calculate a potential $3.8 million price for Bitcoin based on its optimal weight in a portfolio.

Market cycles during which Ark Invest employs different strategies. In bear markets, they concentrate on their highest conviction names, and in bull markets, they diversify into new opportunities like IPOs.

A compensation plan for Elon Musk that would grant him an additional 12% stake in Tesla over 10 years if he meets extremely ambitious performance targets. The vote on this package is a major point of contention and a test of corporate governance.