profluent bio
A Berkeley-based startup that developed an open-source AI gene editor named OpenCrisper-1 using a protein language model.
First Mentioned
10/22/2025, 4:07:38 AM
Last Updated
10/22/2025, 4:09:44 AM
Research Retrieved
10/22/2025, 4:09:44 AM
Summary
Profluent Bio is a Berkeley-based startup that has developed and open-sourced a novel gene editing tool utilizing AI. This innovation, named OpenCrisper-1, was created using their protein language model, which is comparable to Large Language Models (LLMs). OpenCrisper-1 is presented as a more effective alternative to existing CRISPR technology. By making this AI-driven gene editing tool open-source, Profluent Bio aims to enable researchers and entrepreneurs to navigate and overcome the patent landscape often controlled by institutions like the Broad Institute, MIT, and Harvard. This strategic move is intended to accelerate advancements across various fields, including life sciences, agricultural technology, industrial biotechnology, and the development of treatments for genetic diseases, by removing obstacles to innovation.
Referenced in 1 Document
Research Data
Extracted Attributes
Type
Biotechnology company
Founded
2022
Acquired
No
Industry
Medical Organizations
Employees
Between 10 - 20
Tech Stack
Google Cloud Platform
Key Product
OpenCrisper-1 (AI-designed gene editor)
Headquarters
San Francisco, CA, United States
Initial Base
Berkeley, CA, United States
Funding Raised
44,000,000 USD
Core Technology
Machine learning models for biomolecules
Publicly Traded
No
Operating Status
Stealth mode
Timeline
- Profluent Bio was founded. (Source: web_search_results)
2022
Web Search Results
- Profluent Bio - Company Profile - Employbl
Employbl # Profluent Bio San Francisco, CA Profluent Bio is a biotechnology company that currently operates in stealth mode. The company was founded in 2022 and is headquartered in San Francisco, California. profluent.bio Twitter LinkedIn Crunchbase ## Company Details ## Founded : 2022 ## Employees : Between 10 - 20 employees ## Raised : $44,000,000 ## Headquarters Location : San Francisco, CA ## Public : No ## Acquired : No ## Founders : Ali Madani [...] Alexander Meeske ## Company Collections These are collections Profluent Biois a part of. Click on the collection name to view similar companies. ## Profluent Bio's Investors Spark Capital ## Profluent Bio's Industries Software CompaniesMedical Organizations ## Profluent Bio's Tech Stack PythonGoogle Cloud Platform HomeJobs SearchApplication TrackerCompanies
- Profluent | Investment - Insight Partners
Born out of pioneering research in artificial intelligence and biology, Profluent Bio develops machine learning models that can read and write biomolecules for human health and industrial applications. Investment Team Dylan Morris Deven Parekh Sectors BioTech/Therapeutics Status Current Investment ## Want to emulate Profluent’s growth? Subscribe to case studies, resources and more ## Thank You! The form was submitted successfully. ## Thanks! [...] # Portfolio Companies AI/ML Ops Architecture, Engineering, and Construction B2B GTM B2C MarTech & Customer Support BioTech/Therapeutics Consumer Cybersecurity Data & Data Mgmt. DevOps eCommerce Enablement Education Energy & Climate Finance & Accounting Financial Services Gaming Government Healthcare Human Capital IT Mgmt Legal & Compliance Manufacturing Marketplace Other Vertical Market SaaS Payments [...] > I could see from the first 10 minutes of the conversation that Insight Partners was way ahead on AI compared to everybody else we were talking to. > > May Habib > Co-Founder & CEO, Writer\ San Francisco, California, U.S. San Francisco, California, U.S. Burbank, California, U.S. Go to home page
- Profluent - LinkedIn
Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins.
- Profluent Bio
## Partnering to author innovation Profluent’s AI writes proteins, whether inspired by natural scaffolds or designed from scratch. ### The minds behind the matter Our expert team combines machine learning and biology to unlock solutions to complex challenges in protein design. ## News Profluent ### Profluent on A.I. Decoded Profluent ### Profluent on A.I. Decoded Profluent ### Generative A.I. arrives in the Gene Editing World of CRISPR Profluent [...] ### Generative A.I. arrives in the Gene Editing World of CRISPR Profluent ### Profluent, spurred by Salesforce research and backed by Jeff Dean, uses AI to discover medicines Profluent ### Profluent, spurred by Salesforce research and backed by Jeff Dean, uses AI to discover medicines ## Applications across industries From new therapeutics to industrial enzymes, our AI-authored proteins are revolutionizing how we address challenges across diverse fields. [...] # Grounded in nature, authored by AI. ## Proteins are the molecular machines enabling life’s biological functions. The next frontier is authoring new biology, and with AI, we have the power to write the future—creating solutions that transform medicine, agriculture, and beyond. At Profluent, we turn possibilities into reality, one protein at a time. ## About OpenCRISPR ### OpenCRISPR The world's first AI-designed gene editor, demonstrating authorship in action. ## Our Partnerships
- Platform - Profluent
Profluent’s platform is built on an uncompromising commitment to scientific rigor, leveraging diverse datasets and advanced AI to tackle complex biological challenges. By aligning cutting-edge research with real-world applications, we deliver innovative protein designs that solve tangible problems—from human health to industrial applications. ### Optimize multiple attributes simultaneously [...] ### Design of highly functional genome editors by modelling CRISPR–Cas sequences Profluent ### Large Language Models Generate Functional Protein Sequences Across Diverse Families Profluent ### Large Language Models Generate Functional Protein Sequences Across Diverse Families Profluent ### Deep Extrapolation for Attribute-Enhanced Generation Profluent ### Deep Extrapolation for Attribute-Enhanced Generation ## Capabilities ### Rigorous science, real solutions. [...] The integration of our frontier foundation models and an in-house wet lab enables us to align every design step in service of the use-cases that matter. This holistic approach creates an emergent capability to tackle complex challenges with precision, adaptability, and scalability, delivering results that redefine what’s possible with proteins. ## Key publications Profluent ### Design of highly functional genome editors by modelling CRISPR–Cas sequences Profluent