Mitochondrial rejuvenation

Extracted Attributes

• Field

  Rejuvenation Medicine

• Key Proponent

  Bryan Johnson

• Target Diseases

  Parkinson's disease and Alzheimer's disease

• Primary Objective

  Reversal of aging through mitochondrial repair or replacement

• Scientific Mechanism

  Mitotherapy (Mitochondrial transplantation)

• Supporting Technology

  AI-accelerated biological discovery

Timeline

• Submission of the research paper "Mitochondria: A Potential Rejuvenation Tool against Aging" to the journal Aging and Disease. (Source: PMC/Aging and Disease)

  2023-05-26

• Acceptance of the research paper "Mitochondria: A Potential Rejuvenation Tool against Aging" for publication. (Source: PMC/Aging and Disease)

  2023-07-12

• Official publication of the study detailing mitochondria as a rejuvenation tool in the journal Aging and Disease. (Source: PMC/Aging and Disease)

  2024-04-01

Rejuvenation

Rejuvenation is a medical discipline focused on the practical reversal of the aging process. Rejuvenation is distinct from life extension. Life extension strategies often study the causes of aging and try to oppose those causes to slow aging. Rejuvenation is the reversal of aging and thus requires a different strategy, namely repair of the damage that is associated with aging or replacement of damaged tissue with new tissue. Rejuvenation can be a means of life extension, but most life extension strategies do not involve rejuvenation.

Web Search Results

• Mitochondrial Health and Ways It's Redefining Anti-Aging Medicine

  ## Clinical Benefits for Skin Rejuvenation and Longevity Medicine Because of the close connection between mitochondria and skin aging, supporting their function can significantly improve the effectiveness of rejuvenation treatments. The following clinical benefits highlight how mitochondrial support can elevate treatment quality and patient outcomes across aesthetic and longevity protocols: [...] ## Clinical Benefits for Skin Rejuvenation and Longevity Medicine Because of the close connection between mitochondria and skin aging, supporting their function can significantly improve the effectiveness of rejuvenation treatments. The following clinical benefits highlight how mitochondrial support can elevate treatment quality and patient outcomes across aesthetic and longevity protocols: [...] 1. Phua QH, Ng SY, Soh BS. Mitochondria: A potential rejuvenation tool against aging. Aging Dis. 2024;15(2):503–516. doi:10.14336/AD.2023.0712. 2. Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61(5):654–666. doi:10.1016/j.molcel.2016.01.028. 3. Xu K, Pang Y, Fan X. Mitochondria in oxidative stress, inflammation, and aging: from mechanisms to therapeutic advances. Signal Transduct Target Ther. 2025;10:190. doi:10.1038/s41392-025-02253-4. 4. Madreiter-Sokolowski CT, Hiden U, Krstic J, et al. Targeting organ-specific mitochondrial dysfunction to improve biological aging. Pharmacol Ther. 2024;262:108710. doi:10.1016/j.pharmthera.2024.108710.

• Mitochondria: A Potential Rejuvenation Tool against Aging - PMC

  avenues for therapeutic interventions in mitochondrial diseases. [...] between aging, heightened ROS levels, and impaired mitochondrial function creates a vicious cycle that accelerates the aging process, thus affecting lifespan and healthspan. [...] a ground-breaking approach to counteract the aging process. Moreover, we will investigate the successful application of mitochondrial transplantation in both animal models and clinical trials, emphasizing its translational potential. Finally, we will discuss the inherent challenges and future possibilities of mitotherapy within the realm of aging research and intervention.

• Mitochondria: A Potential Rejuvenation Tool against Aging

  #### 模态框（Modal）标题 #### 模态框（Modal）标题 #### Please choose a citation manager #### Content to export # Mitochondria: A Potential Rejuvenation Tool against Aging Mitochondria: A Potential Rejuvenation Tool against Aging | Received | Accepted | Published | --- | 2023-05-26 | 2023-07-12 | 2024-04-01 | | Just Accepted Date | Issue Date | | | 2023-10-03 | 2024-03-06 | | ### HeighLight ### Abstract ### Key words {{custom\_keyword}} / ### Cite this article EndNote Ris (Procite) Bibtex ### {{custom\_sec.title}} #### {{custom\_sec.title}} ### References | | | --- | | {{custom\_ref.label}} | {{custom\_citation.content}} | ### References ### {{custom\_ack.title\_en}} ### RIGHTS & PERMISSIONS Accesses Citation Altmetric Detail #### Contents #### About #### Authors [...] Altmetric Detail #### Contents #### About #### Authors #### Reviewers Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA Fax: (817) 735-0408 E-mail: ditorial@aginganddisease.org Copyright © 2021 Aging and Disease, All Rights Reserved. Powered by Beijing Magtech Co. Ltd / | | | | --- | 〈 | | 〉 |

• 7 Ways To Support Your Mitochondria For Better Health & Ageing

  Improves Metabolic Flexibility: During fasting, the body switches from using glucose to fatty acids and ketones for energy, reducing reactive oxygen species (ROS) production. This shift protects mitochondria from oxidative damage and improves their function. Increases Production of Key Molecules: Fasting boosts the production of sirtuins, NAD+, and ketones, all of which support mitochondrial function and energy production. Promotes Autophagy: This is the body’s process of cleaning out damaged cells and regenerating new ones. This helps remove dysfunctional mitochondria, reducing oxidative stress and maintaining a healthy mitochondrial population. [...] ## How Do Mitochondria Impact Ageing and Cognitive Decline? Mitochondrial function naturally declines with age, leading to reduced cellular energy production and increased oxidative stress. During energy production, mitochondria generate reactive oxygen species (ROS) as a by-product. Over time, excess ROS can damage mitochondrial DNA, impairing efficiency and creating a cycle of further oxidative stress. This process contributes to age-related decline and is linked to conditions such as cardiovascular disease, metabolic dysfunction, and neurodegenerative disorders including Alzheimer’s and Parkinson’s disease. [...] Use Natural Cleaning Products: Many conventional cleaning products contain harsh chemicals that can affect mitochondrial function. Natural alternatives such as vinegar, baking soda, and simple plant-based products are often better tolerated. ### 7. Prioritise Sleep and Stress Regulation Sleep is essential for mitochondrial repair and regeneration. During deep sleep, cells repair oxidative damage and restore energy-producing capacity. Chronic stress, poor sleep quality, blood sugar instability, and cortisol dysregulation often interact to suppress mitochondrial function. Addressing sleep and stress together, rather than in isolation, is frequently key to restoring energy, resilience, and cognitive clarity.

• Mitochondria: 10 Ways to Boost the Powerhouse of Your Cells

  NAD levels decrease naturally in many tissues as we age. This decrease may also contribute to the aging process. However, we can boost NAD+ levels by supplying cells with nutrients that can help them optimize NAD+ metabolism. Doing so may counterbalance the age-related decrease in NAD+ and help support mitochondrial function, protect against age-related diseases, and support longevity. ### Final Thoughts Mitochondria sustain human life because they generate the energy that powers our cells. By supporting mitochondrial fitness, we are supporting the optimal functioning of pretty much every cell and system in the body. Boosting mitochondria can help us live a long and healthy life. [...] Ad is the most successful approach to enhance longevity. This success can be attributed, at least partially, to an increase in mitochondrial bioenergetic efficiency. Calorie restriction acts as a stress signal that triggers a number of adaptations in mitochondria: It improves the activity of the electron transport chain and regulates the production of ROS and oxidative stress. It supports mitochondrial quality control mechanisms, responsible for preventing and/or repairing damage. It promotes the renewal of the mitochondrial network through the elimination of damaged mitochondria (autophagy) and the production of new mitochondria (biogenesis). #### 2. Exercise