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FOXO3 Gene

ScientificConcept

A specific gene that was targeted in the Chinese age reversal study. When overexpressed in stem cells, it was shown to trigger significant age-reversing effects across multiple tissues in monkeys.

entitydetail.created_at

7/13/2025, 5:56:23 PM

entitydetail.last_updated

7/22/2025, 4:45:32 AM

entitydetail.research_retrieved

7/13/2025, 6:07:20 PM

Summary

The FOXO3 gene, also known as FOXO3 or FOXO3a, encodes the human protein Forkhead box O3. This gene has gained prominence due to its involvement in a significant breakthrough in age reversal research originating from China, a development highlighted in recent discussions. It is a key member of the FOXO subfamily of forkhead transcription factors, playing vital roles in regulating various cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage response, and tumorigenesis.

Referenced in 1 Document
Research Data
Extracted Attributes
  • Aliases

    FOXO3, FOXO3a, Forkhead box O3, FKHRL1, FKHRL1P2, FOXO2

  • Organism

    Human

  • Protein Type

    Transcription factor

  • Field of Study

    Genetics, Molecular Biology, Gerontology

  • Biological Role

    Regulates cellular processes (apoptosis, proliferation, cell cycle progression, DNA damage, tumorigenesis), responds to cellular stresses (UV irradiation, oxidative stress), regulates vascular aging, involved in age reversal

  • Encoded Protein

    Forkhead box O3 (FOXO3) protein

  • Chromosome Location

    6q21

Wikipedia
View on Wikipedia
FOXO3

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.

Web Search Results
  • FOXO3 - Wikipedia

    Wikipedia # FOXO3 Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. [...] | FOXO3 | | | | | --- | --- | --- | --- | | | | | | | | Available structures | | | | | --- | --- | --- | --- | | PDB | Ortholog search: PDBe RCSB | | | | List of PDB id codes | | | --- | --- | | 2K86, 2LQH, 2LQI, 2UZK | | | | | | | | Identifiers | | | | | Aliases | FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3 | | | | External IDs | OMIM: 602681; MGI: 1890081; HomoloGene: 31039; GeneCards: FOXO3; OMA:FOXO3 - orthologs | | | [...] | | Orthologs | | | | | --- | --- | --- | --- | | Species | Human | Mouse | | Entrez | | | | --- | | 2309 | | | | | --- | | 56484 | | | Ensembl | | | | --- | | ENSG00000118689 | | | | | --- | | ENSMUSG00000048756 | | | UniProt | | | | --- | | O43524 | | | | | --- | | Q9WVH4 | | | RefSeq (mRNA) | | | | --- | | NM\_001455 NM\_201559 | | | | | --- | | NM\_019740 NM\_001376967 | | | RefSeq (protein) | | | | --- | | NP\_001446 NP\_963853 | | | | | --- | | NP\_062714 NP\_001363896 | | |

  • Critical role of FOXO3a in carcinogenesis - Molecular Cancer

    The member of FOXO subfamily, FOXO3a, also known as FOXO3 or forehead in rhabdomyosarcoma-like 1 (FKHRL1), was first identified in human placental cosmid. The FOXO3a gene is located on chromosome 6q21 [13:187–99.")] and it plays vital role in regulating a variety of cellular processes through targeting the expression and activity of effector genes. The subcellular localization of FOXO3a is important for its activities and functions [14:2229–37.")]. The phosphorylation of FOXO3a leads to its [...] The forkhead box class O (FOXO) family is a ubiquitously expressed transcription factor that plays important role in higher organisms. The first member of this family with fork head was described in Drosophila, which plays key roles in the terminal development of Drosophila embryo [8:645–58.")]. The mammalian system consists of four members, namely FOXO1, FOXO3a, FOXO4, and FOXO6, which are known to be regulated by the phosphoinositol-3-kinase (PI3K)-PKB signaling pathway [...] FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress. The function of FOXO3a is regulated by a complex network of processes, including post-transcriptional suppression by microRNAs (miRNAs), post-translational modifications (PTMs) and protein–protein

  • 2309 - Gene ResultFOXO3 forkhead box O3 [ (human)] - NCBI

    Transcriptional factor FoxO3a is a direct up-stream of SIRT6 and positively regulated SIRT6 expression, which in turn, promotes apoptosis by

  • FOXO3 – A Major Gene for Human Longevity - PMC - PubMed Central

    FoxO3 acts in cardiomyocytes to regulate autophagy, proliferation, cell size and cell survival [46]. It has been suggested that FoxO3 serves both a positive and

  • Longevity Factor FOXO3: A Key Regulator in Aging ... - Frontiers

    The purpose of this review is to explore how FOXO3 regulates vascular aging and its crucial role in aging-related vascular diseases.