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Shinya Yamanaka

Person

Nobel Prize-winning scientist who discovered cellular rejuvenation proteins.


First Mentioned

2/28/2026, 10:59:38 PM

Last Updated

2/28/2026, 11:04:07 PM

Research Retrieved

2/28/2026, 11:04:07 PM

Summary

Shinya Yamanaka is a Japanese stem cell researcher and physician renowned for discovering that mature cells can be reprogrammed into pluripotent stem cells (iPS cells). Born on September 4, 1962, in Higashiosaka, Japan, he currently serves as a professor and director emeritus at Kyoto University's Center for iPS Cell Research and Application (CiRA), while also holding senior positions at the Gladstone Institutes and the University of California, San Francisco. His pioneering work, specifically the identification of the "Yamanaka factors," earned him the 2012 Nobel Prize in Physiology or Medicine, shared with John Gurdon. Beyond basic research, his discoveries have laid the foundation for modern anti-aging therapeutics and regenerative medicine, including recent human clinical trials for curing blindness led by organizations like Life Biosciences.

Referenced in 1 Document
Research Data
Extracted Attributes
  • Nationality

    Japanese

  • Date of Birth

    1962-09-04

  • Key Discovery

    Induced Pluripotent Stem Cells (iPS cells)

  • Field of Study

    Stem cell research and anatomy

  • Place of Birth

    Hiraoka, Higashiosaka, Japan

  • Current Position

    Director Emeritus and Professor, Center for iPS Cell Research and Application (CiRA), Kyoto University

  • Academic Affiliation

    Professor of Anatomy, University of California, San Francisco (UCSF)

  • Research Affiliation

    Senior Investigator, Gladstone Institutes

Timeline
  • Born in Higashiosaka, Japan. (Source: NobelPrize.org)

    1962-09-04

  • Received the NAIST Award from the Nara Institute of Science and Technology. (Source: Gladstone Institutes)

    2003-01-01

  • Awarded the Meyenburg Cancer Research Award for the artificial generation of stem cells. (Source: Wikipedia)

    2007-01-01

  • Founded the Center for iPS Cell Research and Applications (CiRA) at Kyoto University. (Source: NobelPrize.org)

    2008-01-01

  • Received the BBVA Foundation Frontiers of Knowledge Award and the Balzan Prize. (Source: Wikipedia)

    2010-01-01

  • Awarded the Wolf Prize in Medicine with Rudolf Jaenisch. (Source: Wikipedia)

    2011-01-01

  • Awarded the Millennium Technology Prize and the Nobel Prize in Physiology or Medicine. (Source: Wikipedia)

    2012-01-01

  • Awarded the Breakthrough Prize in Life Sciences for his work on iPS cells. (Source: Wikipedia)

    2013-01-01

Shinya Yamanaka

Shinya Yamanaka (山中 伸弥, Yamanaka Shin'ya; born September 4, 1962) is a Japanese stem cell researcher and a Nobel Prize laureate. He is a professor and the director emeritus of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application, Kyoto University; as well as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California and a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR). He received the 2010 BBVA Foundation Frontiers of Knowledge Award in the biomedicine category, the 2011 Wolf Prize in Medicine with Rudolf Jaenisch, and the 2012 Millennium Technology Prize together with Linus Torvalds. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work.

Web Search Results
  • Shinya Yamanaka – Facts - NobelPrize.org

    ## Nobel Prizes and laureates. ## Nobel Prize in Physiology or Medicine 2012. # Nobel Prize. Nobel Prize in Physiology or Medicine 2012. Shinya Yamanaka was born in Higashiosaka, Japan. After spending several years at the Gladstone Institute at the University of California, San Francisco, he returned to Osaka, but later moved to the Nara Institute of Science and Technology, where he began his Nobel Prize-winning research. Shinya Yamanaka was born in Higashiosaka, Japan. After spending several years at the Gladstone Institute at the University of California, San Francisco, he returned to Osaka, but later moved to the Nara Institute of Science and Technology, where he began his Nobel Prize-winning research. ### Nobel Prizes 2025. #### About the Nobel Prize organisation. ##### The prize-awarding institutions. For more than a century, these academic institutions have worked independently to select Nobel Prize laureates. Several outreach organisations and activities have been developed to inspire generations and disseminate knowledge about the Nobel Prize.

  • Shinya Yamanaka – Biographical - NobelPrize.org

    The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. In addition, after hearing about a big scandal involving a Korean researcher who falsely reported the successful generation of human ES cells by cloning at around that time, I thought we should repeat our experiments to make sure of the result so that no researcher could cast doubt on our findings. Encouraged by this support, in January 2008, about two months after we reported the generation of the human iPS cells, Kyoto University founded the Center for iPS  Cell  Research  and  Applications  (CiRA), the world’s first organization solely focusing on iPS cell technology, under the auspices of the Institute for Integrated Cell-Material Sciences (iCeMS).

  • Shinya Yamanaka - Wikipedia

    **Shinya Yamanaka** (山中 伸弥, *Yamanaka Shin'ya*; born September 4, 1962) is a Japanese stem cell researcher and a Nobel Prize laureate. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In October 2012, he and fellow stem cell researcher John Gurdon were awarded the Nobel Prize in Physiology or Medicine "for the discovery that mature cells can be reprogrammed to become pluripotent.". * Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University. **^** "Meyenburg Cancer Research Award 2007 given to Dr. Shinya Yamanaka for the artificial generation of stem cells". "Gladstone's Shinya Yamanaka Wins Prestigious Shaw Prize for Stem Cell Discoveries". * "Shinya Yamanaka 2010 Balzan Prize for Stem Cells: Biology and Potential Applications".

  • Shinya Yamanaka, MD, PhD - Gladstone Institutes

    Director Emeritus and Professor, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan. He is also a professor of anatomy at UC San Francisco, as well as a director and professor of the Center for iPS Cell Research and Application (CiRA) at Kyoto University in Japan. In addition, he has received many awards and honors, including the Albert Lasker Basic Medical Research Award, the Wolf Prize in Medicine, the Millennium Technology Award, the Shaw Prize, the Kyoto Prize for Advanced Technology, the Gairdner International Award, the Robert Koch Award, and the March of Dimes Prize. 2013 The 2013 Kyoto University Shi-Shi Award, Japan. 2013 Special Honor Award of the Kyoto Medical Association, Japan. 2012 Kyoto Prefecture People’s Honor Award, Japan. 2008 Special Prize, Kyoto Souzousya Taisho Awards, Japan. 2008 Takeda Prize for Medical Science, Japan. 2008 Inoue Prize for Science, Japan. 2007 Twenty-Fifth Osaka Science Prize, Japan. 2003 NAIST Award, Nara Institute of Science and Technology, Japan.

  • Shinya Yamanaka's 2012 Nobel Prize and the radical change ... - PMC

    We orthopedic surgeons should continue to search for better treatments for chondral lesions using iPSCs. The research group of Maekawa and Yamanaka successfully reduced the risk of contamination of incompletely reprogrammed cells, which are at risk of tumorigenicity, by introducing Klf4, Oct3/4, Sox2 and Glis1 instead of c-Myc. This technique, though not perfect, can facilitate clinical trials using iPSCs. In 2010, Fukuda’s group described a simple procedure to induce mesenchymal progenitors with chondrogenic properties from mouse iPSCs, suggesting that iPSCs may be alternative sources for transplantation of autogenous mesencymal stem cells to treat cartilage defects. However, in the transplantation of iPSC-derived neural stem cells, intraspinal tumor formation was observed, even though the iPSC-derived neural stem cells were established by 3 of Yamanaka’s 4 reprogramming factors except c-Myc. Therefore, before start of a clinical trial, tumorigenicity analysis is necessary in each cell line prior to transplantation.