Weight Loss

Extracted Attributes

• Types

  Unintentional (due to malnourishment or underlying disease) or deliberate (conscious effort to improve overweight or obese state).

• Definition

  Reduction of total body mass, including fluid, body fat (adipose tissue), or lean mass (bone mineral deposits, muscle, tendon, and other connective tissue).

• Key Drug Class

  GLP-1 drugs

• AI in Healthcare Role

  Positive force for patient empowerment

• Top-selling Drug (Q2)

  Tirzepatide

• Revolutionary Therapy for

  Weight Loss, Obesity

• Impacted Markets by GLP-1s

  SSRIs (potential disruption)

• Goal for Initial Weight Loss

  5% of current weight

• Market Challenges for GLP-1s

  Counterfeit products (from China), Patent Hacking (influenced by American Invents Act), challenging investment climate for Biotech VC.

• Recommended Weight Loss Pace

  Gradual, steady pace (about 1 to 2 pounds a week)

• Unexplained Weight Loss Term

  Cachexia

• Deliberate Weight Loss Strategies

  Healthy eating patterns, regular physical activity, enough sleep, stress management, calorie reduction, consumption of fruits, vegetables, whole grains, healthy fats, time-restricted eating, intermittent fasting, bariatric surgery.

• Initial Indication for GLP-1 drugs

  Diabetes

• Next Frontier for Pharma Innovation

  Brain Diseases

• Risks of Rapid Weight Loss (>2 lbs/week)

  Loss of muscle, water, and bone density; side effects including gallstones, gout, fatigue, constipation, diarrhea, nausea; higher likelihood of regaining weight quickly.

• Anticipated Future Applications of GLP-1s

  Curbing addictions, treating mental health conditions.

• Industry Issues Mentioned by Eli Lilly CEO

  Role of Pharmacy Benefit Managers (PBMs), efficiency of NIH funding, outdated FDA regulations affecting pharma advertising.

• Associated Health Conditions (Improved by weight loss)

  Diabetes, Heart Disease, High Blood Pressure, Sleep Apnea

Timeline

• An early study in Singapore first demonstrated Tirzepatide's profound weight-loss effects. (Source: summary)

  Not specified

• Tirzepatide surpassed Keytruda as the world's top-selling drug in Q2. (Source: document)

  Not specified

• Eli Lilly commits aggressive capital allocation towards expanding its supply chain by building numerous manufacturing plants in the United States for GLP-1 drugs. (Source: document)

  Ongoing

Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue). Weight loss can either occur unintentionally because of malnourishment or an underlying disease, or from a conscious effort to improve an actual or perceived overweight or obese state. "Unexplained" weight loss that is not caused by reduction in calorific intake or increase in exercise is called cachexia and may be a symptom of a serious medical condition.

Web Search Results

• Weight loss: 6 strategies for success - Mayo Clinic

  Eat at least four servings of vegetables and three servings of fruits a day. Snack on fruits and veggies if you get hungry between meals. Have whole grains, such as brown rice, barley, and whole-wheat bread and pasta. Eat fewer refined grains, such as white rice and white bread. Use healthy fats, such as olive oil, vegetable oils, avocados, nuts, nut butters and nut oils. But keep in mind that even healthy fats are high in calories. [...] Losing 5% of your current weight may be a good goal to start with. If you weigh 180 pounds (82 kilograms), that's 9 pounds (4 kilograms). Even this amount of weight loss can lower your risk of some long-term health conditions. Those conditions include heart disease and type 2 diabetes. [...] ### 4. Enjoy healthy foods To lose weight, you need to lower the total calories you take in from food and drinks. But your meals can still be tasty and simple to make. One way that you can take in fewer calories is to eat more fruits, vegetables and whole grains. These are known as plant-based foods. They're low in calories and high in fiber. Fiber helps you feel full. You can eat many kinds of plant-based foods to help you reach your goals. Follow these other diet tips too:

• Steps for Losing Weight | Healthy Weight and Growth - CDC

  Healthy weight loss includes a lifestyle with healthy eating patterns, regular physical activity, enough sleep, and stress management. The five steps on this page can help you get started. Image 7: Two people walking in park and carrying hand weights. Overview [...] A lifestyle with good nutrition, regular physical activity, stress management, and enough sleep supports a healthy weight. People who lose weight at a gradual, steady pace—about 1 to 2 pounds a week—are more likely to keep the weight off than people who lose weight quicker. Factors, such as medicines, medical conditions, stress, genes, hormones, environment, and age can also affect weight management. [...] Weight-loss surgery, also known as bariatric surgery, is an operation that makes changes to the digestive system. Body image Creating a positive body image through healthy eating habits. Strategies for success Find resources to help you lose or gain weight safely and effectively. Weight management for youth Address weight issues in children and teens with healthy guidelines, links to interactive and skill-building tools, and other resources. What you should know about popular diets

• The Mayo Clinic Diet: A weight-loss program for life

  In general, losing weight by following a healthy, nutritious diet — such as the Mayo Clinic Diet — can reduce your risk of weight-related health problems, such as diabetes, heart disease, high blood pressure and sleep apnea. If you already have any of these conditions, they may be improved dramatically if you lose weight, regardless of the diet plan you follow. [...] It focuses on changing your daily routine by adding and breaking habits that can affect your weight. Simple habits, such as eating more fruits and vegetables, not eating while you watch TV, and moving your body for 30 minutes a day, can help you lose weight. The Mayo Clinic Diet is based on the latest behavior-change science, which will help you find your inner motivation to lose weight, set achievable goals and learn to handle setbacks. [...] Most people can lose weight on almost any diet plan that restricts calories — at least in the short term. The goal of the Mayo Clinic Diet is to help you keep weight off permanently by making smarter food choices, learning how to manage setbacks and changing your lifestyle.

• Diet for rapid weight loss Information | Mount Sinai - New York

  Rapid weight loss diet is a type of diet in which you lose more than 2 pounds (lb) or 1 kilogram (kg) a week over several weeks. To lose weight this quickly you must eat very few calories. Image 2: Yo-yo dieting Slow and steady weight loss is the only way to avoid yo-yo dieting, where you lose a great deal of weight, only to regain it within a few months or years. There are no miracles in weight loss, go for steady progress toward a healthier life. [...] Possible Health Concerns You should only follow one of these diets with the help of your provider. Losing more than 1 or 2 lb (0.5 to 1 kg) a week is not safe for most people. It can cause you to lose muscle, water, and bone density. Rapid weight loss can also cause some side effects including: Gallstones Gout Fatigue Constipation Diarrhea Nausea People who lose weight quickly are also more likely to gain back the weight quickly. This can lead to other health problems.

• Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance

  There is no single best strategy for weight management, although some evidence-based methods have been suggested (Table 1). Reducing daily calorie intake is the most important factor for weight loss. Low-calorie recipes, especially those for low-fat or low-carbohydrate diets, have been suggested as the first dietary strategy, although in some cases, a VLCD is required for a short period. Except for energy deficit, there seems to be no significant difference between macronutrient [...] Eating breakfast and avoiding late-night eating should be considered important dietary strategies not only for weight loss, but also for metabolic health and are based on the physiologic clock. Time-restricted eating or intermittent fasting can be considered other options for weight loss and its maintenance. Maintenance of a low-calorie intake should be continued throughout an individual’s lifespan. Thus, the best diet for weight management is one that can be maintained in the long term. [...] diets.78 A systemic review suggested that vegetarian diets reduce mean body weight, but the studies are few and of variable quality.79 Since fish and seafood are excluded, this diet is low in omega-3 fats.

• Instance Of

  Q21664088