Longevity Research

Core Focus

Understanding the aging process

Key Concept

Cellular Rejuvenation

Primary Goal

Extend healthy human lifespan and healthspan

Field of Study

Regenerative medicine

Related Concept

Yamanaka factors (for cellular reprogramming)

Recent Breakthrough

Discovery of proteins 50 times more effective than Yamanaka factors for cellular rejuvenation

Application of Breakthrough

Anti-aging therapeutics

Model Organisms (General Field)

Dogs (Dog Aging Project)

Technology Used in Breakthrough

Specialized LLM, GPT-4B micro

Influencing Factors (General Field)

Lifestyle (e.g., healthy diet, regular exercise, healthy weight, no smoking, moderate alcohol, hydration, socializing, positive thinking)

2021-XX-XX

In 2021, InsideTracker launched the podcast Longevity by Design to serve as a platform for leading longevity scientists to unpack the complexities of cutting-edge research while answering the key question how can we live a healthier, longer life? Throughout season two, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, interviewed scientists with expertise spanning many different disciplines within longevity science. They unlocked exciting information about new research findings, ongoing studies, [...] Clinical trials investigating lifespan and longevity outcomes are typically conducted in animals first. And while findings from animal studies don’t always translate to humans, they offer many relevant insights. Dr. Matt Kaeberlein is the co-director of the Dog Aging Project. The goal of the Dog Aging Project is to understand how genes, lifestyle, and environment influence aging and then use this information to help pets and people increase their healthspan. [...] Dr. Heidi Tissenbaum’s research analyzes this difference between healthspan and lifespan using C. elegans as model organisms. C. elegans are a species of roundworm that has human-like physiological changes, making it a valuable model for aging research. "In aging research, people often use lifespan synonymously with aging, but they're not the same. Lifespan is a measurement of the aging process, but the aging process is much more than how long a person lives. So we can look at two people that

## Latest Research and Reviews ### Unlocking longevity through the comparative biology of aging Rechsteiner and colleagues explore how studying lifespan and disease resistance across species reveals natural adaptations that promote longevity. The authors summarize new discoveries and discuss approaches and recommendations for comparative aging research. + Cheyenne Rechsteiner + Francesco Morandini + Vera Gorbunova Reviews Nature Aging

Researchers from Harvard University looked at factors that might increase the chances of a longer life. Using data collected from men and women from the Nurses’ Health Study and Health Professionals Follow-up Study who were followed for up to 34 years, researchers identified five low-risk lifestyle factors: healthy diet, regular exercise (at least 30 minutes daily of moderate to vigorous activity), healthy weight (as defined by a body mass index of 18.5-24.9), no smoking, and moderate alcohol [...] In a follow-up study, the researchers found that those factors might contribute to not just a longer but also a healthier life. They saw that women at age 50 who practiced four or five of the healthy habits listed above lived about 34 more years free of diabetes, cardiovascular diseases, and cancer, compared with 24 more disease-free years in women who practiced none of these healthy habits. Men practicing four or five healthy habits at age 50 lived about 31 years free of chronic disease, [...] 5. Moderate alcohol – Research finds that moderate drinking, defined as 1 drink daily for women and 2 drinks daily for men, is associated with lower risk of type 2 diabetes, heart attacks, and early death from cardiovascular disease. Low to moderate amounts of alcohol raises levels of “good” cholesterol or high-density lipoprotein (HDL) and prevent small blood clots that can block arteries. However, because alcohol intake—especially heavier drinking—is also associated with risks of addiction,

The study of longevity genes is a developing science. It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood. A few of the common variations (called polymorphisms) associated with long life spans are found in the_APOE_, _FOXO3_, and _CETP_ genes, but they are not found in all individuals with exceptional longevity. It is likely that variants in multiple genes, some of [...] International longevity studies include the SardiNIA Project and theOkinawa Centenarian Study. PubMed provides articles forfurther reading on this topic.Image 14: From the National Institutes of Health Topics in the Genetics and Human Traits chapter Collapse Section [...] of the very old, the centenarians on Sardinia include a significant proportion of men. Researchers are studying whether hormones, sex-specific genes, or other factors may contribute to longer lives among men as well as women on this island.