Age Reversal

Extracted Attributes

• Field

  Medical discipline

• Mechanism

  Repair of age-associated damage or replacement of damaged tissue

• Distinction

  Different from life extension, which aims to slow aging by opposing causes

• Primary Goal

  Practical reversal of the aging process

• Research Methods

  Lifestyle changes (exercise, healthy diet, high-quality sleep), drug regimes (metformin, vitamin D3, doxazosin, alpha-ketoglutarate), chemical means, gene therapy

• Associated Concept

  Rejuvenation

• Potential Applications

  Regenerative medicine, treatment of age-related diseases, whole-body rejuvenation

Timeline

• Alex Plesa began working on the Ichor research project at the Wyss Institute, applying genetic screening techniques to aging. (Source: Web Search Results)

  2020-XX-XX

• A study by Anderson JA et al. published in Elife demonstrated that lifestyle changes, including exercise, a drug regime (metformin), and vitamin D3 supplementation, are capable of slowing down or reversing an aging clock. (Source: Web Search Results)

  2021-04-06

• A review by Duan R et al. on the 'Epigenetic clock' as a promising biomarker and practical tool in aging was published in Ageing Research Reviews. (Source: Web Search Results)

  2022-10-04

• Positive results were reported in reversing blindness in monkeys, leading to preparations for human clinical trials of age reversal gene therapy by a Harvard Medical School lab. (Source: Web Search Results)

  2023-04-XX

• A breakthrough in age reversal from China involving the FOXO3 Gene was reported. (Source: Document 916f3392-52d1-41a3-9336-492ebf4e47a1)

  Recent

Rejuvenation

Rejuvenation is a medical discipline focused on the practical reversal of the aging process. Rejuvenation is distinct from life extension. Life extension strategies often study the causes of aging and try to oppose those causes to slow aging. Rejuvenation is the reversal of aging and thus requires a different strategy, namely repair of the damage that is associated with aging or replacement of damaged tissue with new tissue. Rejuvenation can be a means of life extension, but most life extension strategies do not involve rejuvenation.

Web Search Results

• Human age reversal: Fact or fiction? - PubMed

  lifestyle changes involving exercise, a drug regime including metformin, and vitamin D3 supplementation are all capable of slowing down or reversing an aging clock. Non-interventional studies have connected high-quality sleep, physical activity, a healthy diet, and other factors to age deceleration. Specific molecules have been associated with the reduction or reversal of predicted biological age, such as the antihypertensive drug doxazosin or the metabolite alpha-ketoglutarate. Although [...] Anderson JA, Johnston RA, Lea AJ, Campos FA, Voyles TN, Akinyi MY, Alberts SC, Archie EA, Tung J. Anderson JA, et al. Elife. 2021 Apr 6;10:e66128. doi: 10.7554/eLife.66128. Elife. 2021. PMID: 33821798 Free PMC article. Epigenetic clock: A promising biomarker and practical tool in aging. Duan R, Fu Q, Sun Y, Li Q. Duan R, et al. Ageing Res Rev. 2022 Nov;81:101743. doi: 10.1016/j.arr.2022.101743. Epub 2022 Oct 4. Ageing Res Rev. 2022. PMID: 36206857 Review. [...] prediction. In the past decade, aging clock studies have shown that several age-related diseases, social variables, and mental health conditions associate with an increase in predicted biological age relative to chronological age. This phenomenon of age acceleration is linked to a higher risk of premature mortality. More recent research has demonstrated that predicted biological age is sensitive to specific interventions. Human trials have reported that caloric restriction, a plant-based diet,

• NEW STUDY: Discovery of Chemical Means to Reverse Aging and ...

  Image 2. Rejuvenation and age reversal of senescent human skin cells by chemical means. Cells in the right two panels have restored compartmentalization of the red fluorescent protein in the nucleus, a marker of youth that was used to find the cocktails, before the scientists confirmed they were younger, based on how genes were expressed. Image credit: J. -H. Yang, Harvard Medical School. Read the full study: DOI: Corresponding Author: David A. Sinclair [...] The implications of this new discovery are far-reaching, opening avenues for regenerative medicine and, potentially, whole-body rejuvenation. By developing a chemical alternative to age reversal via gene therapy, this research could revolutionize the treatment of aging, injuries and age-related diseases and offers the potential for lower costs and shorter timelines in development. On the heels of positive results in reversing blindness in monkeys in April 2023, preparations for human clinical [...] trials of the lab’s age reversal gene therapy are in progress.

• Ichor: Reversing Aging - Wyss Institute

  Plesa and his team started by analyzing human fibroblasts using RNA sequencing and gene network data to identify genes that are highly connected to biological processes that change during aging. They then created a “transcriptome clock” that incorporates information from multiple processes to determine the “age” of a given cell. Finally, they activated candidate genes to see which of them can turn back the transcriptome clock and revert cells to a younger state. This approach allows the team to [...] More than 150,000 people die each day across the globe, about two-thirds of them from age-related causes like cancer, neurodegenerative diseases, and cardiovascular disease. If the process of aging could be slowed or reversed, the incidence of these conditions would be dramatically reduced, and more humans would live longer, healthier lives. However, aging is a complex process involving multiple biological systems – there is no single biomarker for aging. Therefore, developing treatments that [...] For several years, Research Fellow Alex Plesa, Ph.D. has been wondering why aging has been treated as an inevitable part of life, and whether there might be a way to alleviate the suffering caused by the spectrum of diseases that afflict all of us as we age. In 2020 he started working on a research project that would eventually become Ichor by applying the genetic screening techniques developed in the lab of Wyss Core Faculty member George Church’s lab to aging.

• More evidence that aging might be reversible - Harvard Health

  young mouse aged dramatically. When the joined blood supplies were disconnected, the organs of the young mouse became biologically younger: in other words, the aging process could be accelerated and then reversed. The scientists then found that in people going through severe COVID-19, surgery for a hip fracture, or pregnancy, the clocks showed a sudden acceleration of aging followed by a reversal. This study did not identify the factors that cause or reverse aging, and we are still a long way [...] illustration of an older man looking into a mirror and seeing a younger version of himself illustration of an older man looking into a mirror and seeing a younger version of himself [...] blog image 1 Avocado nutrition: Health benefits and easy recipes blog image 1 Swimming lessons save lives: What parents should know blog image 1 Preventing and treating iliotibial (IT) band syndrome: Tips for pain-free movement blog image 1 Wildfires: How to cope when smoke affects air quality and health blog image 1 What can magnesium do for you and how much do you need? # More evidence that aging might be reversible ## News briefs

• Can we slow aging? - National Institutes of Health (NIH) |

  Image 10: A happy older couple enjoying a healthy breakfast together at home. Studies have found that healthy eating can help to stave off the effects of aging. PeopleImages.com - Yuri A / Shutterstock Age-reversing therapies like these are still some way in the future. Are there measures people can take now to at least slow the aging process? [...] Before you can tell if a treatment could slow or even reverse aging, you need to know how fast someone is aging in the first place. It’s no secret that people age at different rates. Some people remain healthy and disease-free well into their ninth or even tenth decade of life. Others develop age-related diseases, such as cancer, heart disease, and dementia, much earlier. The concept of “biological age” is often used to describe these differences. Biological age reflects the molecular damage [...] suggested that something in the young mice’s blood could reverse the age-related loss of plasticity.