Biological Age Test
A method to assess the functional age of the body and its individual organs, which can differ from chronological age. Johnson uses it as a key performance indicator for his health regimen.
First Mentioned
10/15/2025, 4:28:52 AM
Last Updated
10/15/2025, 4:29:21 AM
Research Retrieved
10/15/2025, 4:29:21 AM
Summary
A Biological Age Test is a biochemical method, often utilizing epigenetic clocks, designed to assess an individual's internal aging by examining molecular modifications that regulate gene expression over time. These tests primarily analyze DNA methylation, which measures the accumulation of methyl groups on DNA molecules, but also incorporate newer methods such as histone code, chromatin accessibility, and nucleosome positioning. Unlike chronological age, biological age can vary across different organs and is significantly influenced by lifestyle, genetics, and overall health conditions. Entrepreneur Bryan Johnson has notably highlighted the importance of biological age, demonstrating its divergence from chronological age in his personal quest for longevity. He advocates for optimizing high-quality sleep as a crucial intervention to improve biological age, asserting that it enhances willpower, mental health, and overall performance, thereby challenging the conventional 'grind' culture. While widely employed in aging research and commercially available, biological age tests are not yet integrated into routine medical care.
Referenced in 1 Document
Research Data
Extracted Attributes
Type
Biochemical test
Purpose
Measure age, assess internal aging, determine vitality, identify age-related diseases, provide insights for health and lifespan, track aging patterns
Distinction
Differs from chronological age
Sample Types
Saliva, Blood
Cost (Commercial)
Several hundred dollars
Primary Mechanism
Epigenetic clocks
Influencing Factors
Lifestyle, genetics, health conditions, age, gender, genetic disposition, expositions
Key Analysis Method
DNA methylation (measuring methyl groups on DNA)
Alternative Assessment
Standard blood tests and physical characteristics (blood pressure, blood sugar, cholesterol levels, heart rate, height, weight) using algorithms
Newer Analysis Methods
Histone code, chromatin accessibility, nucleosome positioning
Current Status (Medical)
Widely used in aging research, not part of routine medical care
Current Status (Commercial)
Widely available online
Characteristics of Effective Tests
Easy to perform, repeatable, cost-effective, preferably non-invasive
Timeline
- Press release for 'EpiAge: A New Test to Measure Biological Age Using Saliva or Blood' published, highlighting its accuracy and convenience using saliva samples. (Source: aging-us.com)
2025-02-24
Wikipedia
View on WikipediaEpigenetic clock
An epigenetic clock is a biochemical test that can be used to measure age. The test is based on modifications that change over time and regulate how genes are expressed. Many epigenetic clocks are based on the analysis of DNA methylation, measuring the accumulation of methyl groups to one's DNA molecules. More recently, new epigenetic clocks have been developed based on the histone code, chromatin accessibility and nucleosome positioning.
Web Search Results
- What is a Biological Age Test? Understanding Your True ...
## What Is a Biological Age Test? A biological age test measures how your body is aging internally by assessing lifestyle, genetics, and health factors, unlike chronological age, which measures years lived. It helps identify whether your body is aging faster or slower than expected, offering insights to improve health and extend lifespan. [...] ## How Do Biological Age Tests Work? Biological age tests measure internal aging by assessing biomarkers like inflammation, metabolic health, and cellular function. Unlike chronological age, which counts years, these tests evaluate cellular and molecular aging to provide a detailed health profile and insights into aging rates. [...] A biological age test is used to determine how well your body is aging internally compared to your chronological age. It identifies areas where your health may need improvement, offering personalized insights for better aging. ### How Is Biological Age Testing Different From Health Checkups?
- A New Test to Measure Biological Age Using Saliva or Blood
diverse populations.Biological age measures how fast or slow a person’s body is aging. It can be different from chronological age and is influenced by genetics, lifestyle, and health conditions. Understanding biological aging can help researchers and clinicians identify age-related diseases like Alzheimer’s disease and develop anti-aging treatments. However, many existing biological age tests rely on expensive and complicated processes. The EpiAgePublic model overcomes these challenges with a [...] Impact Journals is a member of the Society for Scholarly Publishing. Learn about our FREE Post-Publication Promotion Services Announcements Press Releases Altmetric Top 100 # EpiAge: A New Test to Measure Biological Age Using Saliva or Blood 02-24-2025 “Our findings demonstrate that epiAgePublic can effectively estimate biological age with an accuracy comparable to more complex, established epigenetic clocks.” Listen to an audio version of this press release [...] simple yet powerful approach.The study analyzed data from over 4,600 individuals across different health conditions, including Alzheimer’s disease and HIV. It confirmed that EpiAgePublic accurately tracks aging patterns and can identify factors such as chronic illness or stress that accelerate the aging process. Importantly, the researchers demonstrated that the test works well using saliva samples, offering a convenient and non-invasive alternative to blood-based tests. This makes it easier to
- Biological Age: What It Is and How You Can Measure It
Biological age estimates are widely used in aging research. But they’re not part of routine medical care yet, notes Dr. Hussain. This isn’t something you’ll get at your annual physical. Despite this, biological age testing is widely available online. You send in a blood or saliva sample, pay several hundred dollars and then, get results sent to you that tell you your biological age. [...] Another way to estimate biological age is to use standard blood tests and physical characteristics. Researchers have developed complex equations (algorithms) that combine various clinical measurements, such as: Blood pressure Blood sugar Cholesterol levels Heart rate Height and weight ### Are commercial biological age tests worthwhile? [...] What if you find out your body is aging faster than your chronological age? Will it inspire you to change your habits? If the answer is yes, then a test may be helpful — a way to jump-start some healthy living changes. But you can also make these changes without the test. ### Can you improve your biological age? “The steady march of time affects us all,” poses Dr. Hussain. “But there are many things you can do to slow the clock. That’s true even if you don’t know exactly how ‘old’ you are.”
- GlycanAge: Biological Age Test - Discover Your Biological Age
Discover your biological age, make lifestyle improvements, track your success. Start your journey and buy a test Available worldwide! GlycanAge is a fabulous, easy-to-use biological age testing kit. You take 4 drops of blood and send it off to the lab. Shortly thereafter you get your results and speak to a specialist to see what more can be optimised. Claudia von Boeselager, Peak Performance and Longevity Coach ## GlycanAge is scientifically proven [...] A single GlycanAge test allows you to discover your current biological age and wellness. Buy now for ### Two tests ⭐ Most popular Multiple tests allow you to track progress towards slowing ageing and help you understand how any lifestyle changes affect your unique biology. Buy now for - Save 15% ## Frequently Asked Questions Need help or further guidance? Ask us anything through our live chat Start your GlycanAge journey today: ## Biohacking and pioneer science [...] Buy tests # GlycanAge - The Best Biological Age Test To Discover, Measure and Optimise your: ## Biohacking and pioneer science Push your limits and prove that your biohacks work Used by our inspiring health pioneers Biohacking stories Validate your theories today ## Health, wellness, and longevity Improve and measure your healthspan. Trusted by many health enthusiasts Longevity and wellness stories Optimise your health today ## Menopause Journey
- Methods for the assessment of biological age – A systematic review
Biological age (BA) is an operational approach to measure someone's vitality, which considers an individual's mental, emotional, physical and social health and can be defined as the functionality of a person . A person's vitality depends on their age, gender, genetic disposition, lifestyle and expositions and strongly differs inter- and intra-individually . BA takes into account a multitude of parameters of different physiological systems, the so-called biomarkers of ageing (BoA). The [...] With an increasingly ageing world population and the resulting health burden, better tools and endpoints are necessary to enable healthy ageing. Biological age has been used as an approach to determine a person's individual age and functional status for many years. Various methods and scores exist to calculate BA. The goal of our systematic review was threefold: to analyse existing methods and BoA to assess BA, to determine whether there are gold standards, and to see what other objectives were [...] Since ageing is a complex multi-systemic process, no single marker can predict BA or ageing rates. BA assessment methods therefore rely on a multitude of BoA, which change with increasing age and are measured through a test battery [1,5]. These tests should be easy to perform, repeatable, cost effective, and preferably non-invasive . The more accurate the parameters used in a test battery represent physiological changes of ageing, the greater its predictive power will be . Challenges that arise