Complex diseases

Extracted Attributes

• Type

  Category of diseases

• Examples

  Various forms of arthritis, lupus, Sjögren's syndrome, Alzheimer disease, autism, heart disease, diabetes, multiple sclerosis, Parkinson disease, osteoporosis, glaucoma, depression, stroke, cancer

• Prevalence

  Extremely common conditions; affect many people

• Alternative name

  Rheumatic diseases

• Nature (Genetics)

  Result from contributions of multiple genomic variants and genes

• Research challenge

  Individual contributions often small and hard to disentangle; difficult to study and treat because specific factors not identified

• Inheritance pattern

  Can be seen running through a family, but pattern may not be very clear

• Nature (Immunology)

  Disorders of the immune system

• Causation (Genetics)

  Not caused by one specific gene; many genes and variants contribute

• Number of conditions

  Over 100

• Common characteristic

  Inflammation in the bones, muscles, joints, and internal organs

• Nature (Environmental)

  Significant influences of physical and social environment

• Alternative name (Genetics)

  Multifactorial diseases

Rheumatology

Rheumatology (from Greek ῥεῦμα (rheûma) 'flowing current') is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatology covers more than 100 different complex diseases, collectively known as rheumatic diseases, which includes many forms of arthritis as well as lupus and Sjögren's syndrome. Doctors who have undergone formal training in rheumatology are called rheumatologists. Many of these diseases are now known to be disorders of the immune system, and rheumatology has significant overlap with immunology, the branch of medicine that studies the immune system.

Web Search Results

• Complex Disease

  A complex disease (or condition), when discussed in the context of genetics, reflects a disorder that results from the contributions of multiple genomic variants and genes in conjunction with significant influences of the physical and social environment. For this reason, complex diseases are also called multifactorial diseases. This stands in contrast to a “simple” genetic disease that is more directly caused by mutations in a single gene. Common examples of complex genetic diseases include [...] A complex disease (or condition), when discussed in the context of genetics, reflects a disorder that results from the contributions of multiple genomic variants and genes in conjunction with significant influences of the physical and social environment. For this reason, complex diseases are also called multifactorial diseases. This stands in contrast to a “simple” genetic disease that is more directly caused by mutations in a single gene. Common examples of complex genetic diseases include [...] Complex Disease. Complex disease really just means that it isn't caused by one specific gene. Many genes and variants contribute to it. Even your environment contributes to it. Often these individual contributions are so small that they're hard for scientists to really disentangle. Calling these kinds of diseases complex implies that other diseases are just simple, which I bet that a lot of people who work on "simple diseases" would disagree with. No gene or protein works in a vacuum, so no

• What is a Complex Disease? - Miller School of Medicine

  Complex diseases are diseases that are caused in large part by genes AND environmental factors. Since complex diseases do have a genetic component, they can be seen running through a family, but the pattern may not be very clear. There are many examples of complex disease: Alzheimer disease, autism, heart disease, diabetes, multiple sclerosis, Parkinson disease, osteoporosis, glaucoma, depression, arthritis, stroke, cancer. ### Research on Complex Diseases [...] You may have noticed that these complex diseases are extremely common conditions! Most of us have a family history of at least one of these diseases. Because these diseases affect so many people, current efforts in genetic research are focused on finding out the genetic and environmental causes for them. If the genetic cause of complex disease is better understood, the diseases can be prevented, better treated and possibly cured. The John P. Hussman Institute for Human Genomics is a leader in [...] complex disease research. The HIHG conducts genetic research studies to find genes for autism, Alzheimer disease, multiple sclerosis, and many many more!

• What is a complex disease? - Your Genome

  new_your_genome new_your_genome Explore Genomics Health and Disease # What is a complex disease? Elderly female hand using an inhaler while having difficulty breathing Elderly female hand using an inhaler while having difficulty breathing ### Many common diseases are influenced by a combination of multiple genes and environmental factors. These diseases are referred to as complex diseases. ## Single nucleotide polymorphisms [...] ### What about conditions that are caused by single genes? Find out more about single gene disorders #### Quick Links #### Contact Support feedback@yourgenome.org #### Produced by Wellcome Connecting Science Wellcome Connecting Science Wellcome Sanger Institute Wellcome Sanger Institute

• What are complex or multifactorial disorders? - Genetics - MedlinePlus

  ## For more information about complex disorders: MedlinePlus provides information about specific complex disorders such as diabetes and obesity. From the National Institutes of Health From the National Institutes of Health The National Human Genome Research Institute (NHGRI) provides information about complex disorders and polygenic risk scores. From the National Institutes of Health From the National Institutes of Health [...] Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance. It may be difficult to identify the role of genetics in these disorders, particularly because families often also share environments and may have similar lifestyles. This makes it difficult to determine a person’s risk of inheriting or passing on these disorders. Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have [...] environmental factors, such as exercise, diet, or pollutant exposures. Conditions caused by many contributing factors are called complex or multifactorial disorders.

• Genetic Disorders: What Are They, Types, Symptoms & Causes

  Chromosomal: This type affects the structures that hold your genes/DNA within each cell (chromosomes). With these conditions, people are missing or have duplicated chromosome material. Complex (multifactorial): These disorders stem from a combination of gene mutations and other factors. They include chemical exposure, diet, certain medications and tobacco or alcohol use. Single-gene (monogenic): This group of conditions occurs from a single gene mutation. [...] Late-onset Alzheimer’s disease. Arthritis. Autism spectrum disorder, in most cases. Cancer, in most cases. Coronary artery disease. Diabetes. Migraine headaches. Spina bifida. Isolated congenital heart defects. Advertisement Monogenic disorders [...] To understand genetic disorder causes, it’s helpful to learn more about how your genes and DNA work. Most of the DNA in your genes instructs the body to make proteins. These proteins start complex cell interactions that help you stay healthy. When a mutation occurs, it affects the genes’ protein-making instructions. There could be missing proteins. Or the ones you have do not function properly. Environmental factors (also called mutagens) that could lead to a genetic mutation include: